Platelet production
Platelets originate from bone marrow megakaryocytes, which derive from pluripotent myeloid stem cells. Platelet production is driven primarily by thrombopoietin (TPO), a hormone that binds to and activates the TPO-R on progenitor cells and megakaryocytes.20,21
References
20. Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene. 2002;21:3359-3367.
21. Kaushansky K. Thrombopoietin. N Engl J Med. 1998;339:746-754.
