Systemic lupus erythematosus
Systemic lupus erythematosus (SLE), a systemic autoimmune disorder primarily affecting women, manifests itself as thrombocytopenia in between 7% and 30% of SLE patients. There are several possible mechanisms through which SLE may bring about immunologically mediated thrombocytopenia, including antiplatelet antibody formation, antiphospholipid antibody formation, and thrombotic microangiopathies. Antithrombopoietin antibodies and damage to megakaryocytes may also play roles.22
References
22. Ziakas PD, Routsias JG, Giannouli S, Tasidou A, Tzioufas AG, Voulgarelis M. Suspects in the tale of lupus-associated thrombocytopenia. Clin Exp Immunol. 2006;145:71-80.
23. Li J, Xia Y, Kuter DJ. Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics. Br J Haematol. 1999;106:345-356.
